Contraindicated (one)pentobarbital will decrease the extent or influence of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the formation and elimination of cariprazine's active metabolites.
Patients stabilized on corticosteroid therapy could have to have dosage adjustments if barbiturates are extra to or withdrawn from their dosage program as a result of induction of hepatic microsomal enzymes by barbiturates
Contraindicated (1)pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can lower panobinostat ranges by ~70% and lead to treatment failure.
pentobarbital will decrease the level or effect of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lower the level or influence of solifenacin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital decreases amounts of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Keep away from Except the coadministration outweighs the feasible chance of ponatinib underexposure; check for indications of lessened efficacy.
pentobarbital will decrease the level or impact of estropipate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will increase outcomes of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Watch. Coadministration of ifosfamide with CYP2B6 inducers might maximize metabolism of ifosfamide to its metabolite. Check for amplified results/toxicities if combined with CYP2B6 inducers.
pentobarbital will decrease the level more info or effect of vinorelbine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Mysterious.
pentobarbital will decrease the extent or result of zaleplon by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Mysterious.
pentobarbital will lower the level or influence of fosphenytoin by influencing hepatic enzyme CYP2C9/ten metabolism. Use Warning/Monitor.
pentobarbital will lower the extent or influence of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will minimize the extent or outcome of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Potent CYP3A4 inducers may perhaps minimize midostaurin concentrations causing minimized efficacy.
buprenorphine, long-acting injection and pentobarbital both equally maximize sedation. Steer clear of or Use Alternate Drug. Restrict use to patients for whom alternate treatment method solutions are inadequate